Ketamine is a prescription-only medicine that may be prescribed off-label by our medical team following a comprehensive assessment to assist in the psychotherapy.
Ketamine is a prescription-only medicine that may be prescribed off-label by our medical team following a comprehensive assessment to assist in the psychotherapy.
Psychedelic-Assisted Psychotherapy · Norfolk, UK
Specialist psychotherapy and medically supervised treatment for people living with depression, anxiety, PTSD, CPTSD, OCD and addiction — who are ready for something that actually works.
Why This Works
The brain rewiring itself
Ketamine temporarily increases the brain’s capacity to form new neural connections — creating a window in which deeply embedded patterns can shift in ways that are difficult or impossible through talking therapy alone.
A different neurological pathway
Unlike antidepressants which target serotonin over weeks, ketamine acts on the glutamate system almost immediately — producing rapid changes in mood and cognition, often within hours of the first session.
Quieting the patterns that keep you stuck
Ketamine temporarily quiets the Default Mode Network — the brain region associated with rumination and negative thought loops — creating space for genuine psychological insight and change.
Safety & Medical Oversight
Every aspect of the Emerge Programme’s medical delivery is overseen by a CQC-registered medical provider. Before any treatment begins, you will have been thoroughly assessed — medically and psychologically — and both Paul and Dr Devany will be satisfied that KAP is appropriate for your specific situation.
Before your first KAP session, you complete a comprehensive medical questionnaire and attend a face-to-face medical assessment with Dr Devany. This covers your full medical history, current medications, contraindications and any factors that might affect how you respond to ketamine.
Medical screening is not a formality. If ketamine-assisted psychotherapy is not medically appropriate for you, we will not proceed — and we will support you to find an alternative pathway that is.
Medical assessment, prescribing, storage and administration of ketamine are provided through a separate CQC-registered medical provider — ensuring full regulatory compliance and the highest standards of clinical governance throughout your programme.
Dr Devany oversees all medical aspects of your treatment. Every ketamine dose is individually prescribed and prepared for your specific treatment plan. All medical monitoring during sessions is conducted to the standards required by the Care Quality Commission.
During every KAP session, Paul is present throughout — available to provide support, adjust the approach or intervene if needed. Dr Devany’s medical oversight means that any physiological concerns during a session are managed immediately and appropriately.
After sessions, the integration process provides a structured space to process anything difficult that arises. Between sessions, you have direct access to Paul. If at any point during the programme either Paul or Dr Devany has concerns about your wellbeing, those concerns will be raised openly and your programme adjusted accordingly.
Medical assessment, prescribing, storage and administration are provided by a separate CQC-registered medical provider. The Emerge Clinic provides psychotherapeutic services and programme coordination only. Ketamine is not licensed in the UK for the treatment of depression, anxiety, PTSD or addiction. Its use is off-label and only considered following comprehensive individual assessment. Results vary between individuals and cannot be guaranteed.
PAUL GIBSON — FOUNDER
From Paul
Everyone who comes through the Emerge Programme works directly with me — from the first conversation to the final integration session. I don’t hand you off to someone else. I don’t delegate the therapeutic relationship. Your programme is mine to deliver, and I take that personally.
I trained in psychedelic-assisted therapy because I believe this approach offers something genuinely different to people who have been failed by conventional treatment. Not a miracle. Not a shortcut. But a real, neurologically grounded opportunity to shift what has felt immovable.
If you’re wondering whether this programme is right for you — that’s exactly the conversation I’d like to have.
Paul Gibson
Founder & Director of Psychotherapeutic Services, The Emerge Clinic
MAPHP · MNRPC · Polaris Insight Center, San Francisco
The Emerge Clinic
Devany Medical
2B Waveney Drive
Gorleston-on-Sea
Great Yarmouth, Norfolk NR31 7BX
I don’t think healing happens because someone receives ketamine.
I think healing happens because somebody finally feels safe enough to tell the truth.
THE SCIENCE
Ketamine’s effects on depression aren’t simply chemical — they’re neurological, structural, and psychological. Understanding what’s actually happening helps explain both why conventional antidepressants often fall short, and why ketamine-assisted psychotherapy can reach places they cannot.
Default Mode Network
Glutamate & NMDA Pathway
BDNF & Neural Regeneration
Psychotherapy Window
That pause is not incidental to the therapy.
It is the opening the therapy works through.
01
In depression, the default mode network becomes chronically overactive — the neurological basis of rumination and the loop of negative, self-focused thought that feels impossible to step out of. Ketamine temporarily quiets this overactivity, creating a pause in the narrative that no conventional antidepressant reliably achieves.
02
Ketamine works on the glutamate system by temporarily blocking NMDA receptors. This triggers a rapid surge in glutamate release, stimulating AMPA receptors and strengthening synaptic connections in key mood-regulating circuits.
03
Chronic depression is associated with reduced BDNF expression, leading to loss of dendritic density and reduced hippocampal volume over time. Ketamine rapidly increases BDNF expression, promoting the growth of new dendrites and synaptic connections.
04
These neurological changes create a window of heightened neuroplasticity and psychological flexibility that typically lasts hours to days. During this time, the brain is more open to forming new patterns — this is when the therapy in KAP does its most important work.
Ketamine is not licensed in the UK for the treatment of depression. Its use in this context is off-label and only considered following comprehensive medical and psychotherapeutic assessment.
MEET THE TEAM
The Emerge Clinic brings together two distinct forms of highly skilled expertise: careful medical oversight and experienced psychedelic psychotherapy.
A SAFE FIRST STEP
Everything you share is treated with the utmost care and discretion.
Not sure if ketamine-assisted psychotherapy is right for you? We’re happy to talk through your questions.
Prefer to talk first? Give us a call during opening hours.
01493 991 088
ONE FINAL THOUGHT…
If you’re ready to talk, I’d love to hear from you. No pressure. Just an honest conversation about what’s going on and how I might help.
WHEN YOU’re ready